.. _simulation:

In silico gene perturbation with GRNs
=====================================

CellOracle leverages the constructed GRN models to simulate signal propagation inside a cell.
Using these calculations with the GRN models, we estimate the effects of gene perturbations.



The jupyter notebook files and data used in this tutorial are available `here <https://github.com/morris-lab/CellOracle/blob/master/docs/notebooks/05_simulation/Gata1_KO_simulation_with_Paul_etal_2015_data.ipynb>`_ .



Python notebook

.. toctree::

   ../notebooks/05_simulation/Gata1_KO_simulation_with_Paul_etal_2015_data